Recommended Lifestyle for ET Patients by Mayo Clinic

March 25, 2011 4 comments

I tried searching for lifestyles and diets for patients with ET. I came upon the following recommendations by Mayo Clinic.

Take extra care to reduce your risk of developing blood clots if you have essential thrombocythemia. Healthy lifestyle habits can lower your risk of developing conditions that may contribute to blood clotting. These conditions include diabetes, high blood pressure and high blood cholesterol. Take steps to:

  • Eat healthy foods. Choose a varied diet rich in whole grains, vegetables and fruits and low in saturated fats. Try to avoid trans fats. Learn about portion control to maintain a normal weight.
  • Increase your physical activity. Aim for at least 30 minutes of moderate physical activity a day. Take a brisk daily walk. Ride your bike. Swim laps. If you can’t fit in a long workout, break it up into smaller sessions spread throughout the day.
  • Achieve or maintain normal weight. Being overweight or obese increases the pressure in the veins in your pelvis and legs and is a risk factor for conditions such as high blood pressure, which increases your risk of blood clotting.
  • Stop smoking. Smoking affects blood clotting and circulation.

If your ET increases your tendency to bleed, take extra precautions to keep from injuring yourself. Follow these suggestions:

  • Avoid playing contact sports or engaging in other activities that could be dangerous or could cause you to fall.
  • Use a softer toothbrush and waxed floss.
  • Avoid shaving cuts. Shave with an electric razor.
  • Be cautious with household tasks involving knives, scissors and other sharp tools.



Platelets Behaving…

March 20, 2011 4 comments

Updates for Mar 2011. I was so relief to find out from my latest count to be at 402. I am off any medication for the past 6 months. I kept asking my haematologist if I am cured since it has not been elevated for the past 6 months. His answer is unfortunately No. This is a blood disorder that has no cure and its currently hovering at that level for me. I was told that some patients are receptive on the medication that they were put on and show no symptoms for few months or even a year. But the platelet counts may escalate again in the near future. I just have to be on constant watchout and get myself tests for platelet counts every 2-3 months. I do hope that this will maintain for years to come or never again escalated to an alarming level. Could a healthy lifestyle, diet and constant exercise could somehow be a good combination? Whether it is a contribution or not, its always better to live with a positive lifestyle and hope for the best that someday medical science will find a cure.

Categories: Medical Updates

Platelet Counts – Normal

February 10, 2011 2 comments

My last examination on Jan 21st, 2011 produced positive results. My platelet counts was at normal level. After been taken off the Interferon alpha treatment for almost 6 months, my platelet counts were pretty stable. I am now currently under observation by my haematologist every 2-3 months to ensure that it is indeed stable. I did asked my haematologist if there is any possibility that I was misdiagnosed since my platelet counts were stable and have not been elevated for about six months now. He confirmed and no doubt that I am suffering from this ET blood disorder. According to him, it is possible for certain patients that the platelets will be stable at a certain time and “might” elevate again later on. Hence, I will be put on observations once every 2-3 months.

It has been a year now and this month (Feb) marks the anniversary of my diagnosis last year in 2010. I do hope that my condition will stabilise and maintain the current positive outlook for years to come.

I just came back from a 10-day trip to Kolkata and Varanasi (India). My visit gave me a broader perspective of life and allow me to understand how fortunate we are living in a developed nation with proper healthcare, good living conditions, proper infrastructure, clean air and water, good transportation and governance. Living conditions in these places that I’ve visited in 10 days could be better. Poverty, cleanliness and hygiene are still an issue to be curbed and I do hope that the nation will take them seriously. I do hope that the nation will have a long-term plan to address these issues.

– Bryan –

Categories: Medical Updates

Incyte Corporation – Phase 2 study of INCB18424 for the treatment of advanced PV and ET

January 3, 2011 2 comments

Incyte Corporation (Incyte Corporation (NASDAQ: INCY) announced positive long-term clinical results from an ongoing open-label Phase 2 trial for INCB18424, in patients with advanced polycythemia vera (PV) and essential thrombocythemia (ET). PV and ET, along with myelofibrosis (MF), are blood cancers that belong to a group of diseases known as myeloproliferative neoplasms (MPNs). This trial (Study 18424-256) is an ongoing, multi-center, single-arm, open-label study being conducted in the United States and Italy. An initial 8-week run-in evaluation established 10mg and 25mg twice daily as starting doses for expansion cohorts in PV and ET, respectively.

For ET patients: After a median follow-up of 21 months, 49% of enrolled patients (n=39) normalized platelet counts, and 79% achieved platelet counts < 600×109/L or a ≥ 50% reduction from baseline. Of the 14 patients with extreme thrombocytosis > 1000×109/L at baseline, 13 (93%) experienced > 50% reduction. WBC counts for patients with baseline counts > 10×109/L normalized within the first month and were maintained for a median duration of 14 months. Palpable spleens completely resolved in 3 of 4 patients with baseline splenomegaly; 1 reduced >50% from baseline.

INCB18424 is a JAK1 and JAK2 inhibitor that has shown positive clinical activity in a number of hematology and inflammatory conditions.

Incyte Corporation:

Categories: Research Updates


January 3, 2011 7 comments

Welcome to “Life with Essential Thrombocytosis”.

This blog is meant to share experience, knowlege, news of new researches on blood disorder, meeting new friends who also suffered from this disorder and hopefully to share our concerns and hope for a better future to find a cure for this blood disorder. This site does not provide a professional medical opinion and will not be responsible for any medical attention or decision for treatments. Please seek a professional Medical Doctor or a Medical Specialist to diagnose and treat your case.

Essential thrombocytosis (ET, also known as essential thrombocythemia) is a rare chronic blood disorder characterized by the overproduction of platelets by megakaryocytes in the bone marrow in the absence of an alternative cause. In some cases this disorder may be progressive, and rarely may evolve into acute myeloid leukemia or myelofibrosis. It is one of four myeloproliferative disorders.

The following YouTube video by Professor Ruben Mesa, MD from MayoClinic provides a quick and informative overview of ET.